woensdag 24 augustus 2011

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Pharmaceutical Product Development: In Vitro-In Vivo Correlation (Drugs and the Pharmaceutical Sciences)From CRC Press

During the last two decades, the pharmaceutical industry has been under pressure to reduce development costs and the time needed to bring drugs to market in order to maximize return on investment and bring treatments to patients sooner. To meet these ends, pharmaceutical scientists working in the differing areas of pharmacy, pharmaceutics, and pharmacokinetics are collaborating to address physicochemical and biological issues in the early stages of development to avoid problems in later stages. In Vitro-In Vivo Correlation (IVIVC) is a multidisciplinary tool that has been successfully applied in testing the effectiveness of a drug substance. The only comprehensive guide available on IVIVC, this source illustrates the emerging importance of IVIVC in the drug development process, and covers the most recent advances and regulatory perspectives on the role of IVIVC in the pharmaceutical industry.

  • Sales Rank: #4098993 in Books
  • Published on: 2007-02-12
  • Original language: English
  • Number of items: 1
  • Dimensions: 9.05" h x .62" w x 6.36" l, .90 pounds
  • Binding: Hardcover
  • 224 pages

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zondag 21 augustus 2011

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  • Published on: 1981-06-01
  • Binding: Paperback

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woensdag 17 augustus 2011

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The Happiness Hypothesis: Finding Modern Truth in Ancient Wisdom, by Jonathan Haidt

In his widely praised book, award-winning psychologist Jonathan Haidt examines the world’s philosophical wisdom through the lens of psychological science, showing how a deeper understanding of enduring maxims-like Do unto others as you would have others do unto you, or What doesn’t kill you makes you stronger-can enrich and even transform our lives.

  • Sales Rank: #34011 in eBooks
  • Published on: 2006-12-26
  • Released on: 2006-12-26
  • Format: Kindle eBook

From Publishers Weekly
Starred Review. The spirit is willing but the flesh is weak, lamented St. Paul, and this engrossing scientific interpretation of traditional lore backs him up with hard data. Citing Plato, Buddha and modern brain science, psychologist Haidt notes the mind is like an "elephant" of automatic desires and impulses atop which conscious intention is an ineffectual "rider." Haidt sifts Eastern and Western religious and philosophical traditions for other nuggets of wisdom to substantiate—and sometimes critique—with the findings of neurology and cognitive psychology. The Buddhist-Stoic injunction to cast off worldly attachments in pursuit of happiness, for example, is backed up by Mihaly Csikszentmihalyi's studies into pleasure. And Nietzsche's contention that what doesn't kill us makes us stronger is considered against research into post-traumatic growth. An exponent of the "positive psychology" movement, Haidt also offers practical advice on finding happiness and meaning. Riches don't matter much, he observes, but close relationships, quiet surroundings and short commutes help a lot, while meditation, cognitive psychotherapy and Prozac are equally valid remedies for constitutional unhappiness. Haidt sometimes seems reductionist, but his is an erudite, fluently written, stimulating reassessment of age-old issues. (Jan.)
Copyright © Reed Business Information, a division of Reed Elsevier Inc. All rights reserved.

From Booklist
Using the wisdom culled from the world's greatest civilizations as a foundation, social psychologist Haidt comes to terms with 10 Great Ideas, viewing them through a contemporary filter to learn which of their lessons may still apply to modern lives. He first discusses how the mind works and then examines the Golden Rule ("Reciprocity is the most important tool for getting along with people"). Next, he addresses the issue of happiness itself--where does it come from?--before exploring the conditions that allow growth and development. He also dares to answer the question that haunts most everyone--What is the meaning of life?--by again drawing on ancient ideas and incorporating recent research findings. He concludes with the question of meaning: Why do some find it? Balancing ancient wisdom and modern science, Haidt consults great minds of the past, from Buddha to Lao Tzu and from Plato to Freud, as well as some not-so-greats: even Dr. Phil is mentioned. Fascinating stuff, accessibly expressed. June Sawyers
Copyright © American Library Association. All rights reserved

Review
"Riveting... Brilliantly synthesising ancient cultural insights with modern psychology and even holding out some faint hope that your happiness, if not your tallness, might be marginally adjustable after all." Sunday Times "Marvellous... Haidt...takes us on an extraordinary journey... I don't think I've ever read a book that laid out the contemporary understanding of the human condition with such simple clarity and sense." -- James Flint Guardian "A superbly argued, crystal clear and intelligent blend of new directions in contemporary experimental psychology with traditional philosophical thought... And you know what? Reading it did actually make this reviewer happier." Arena "A delightful book... By some margin the most intellectually substantial book to arise from the 'Positive Psychology' movement." Nature "With singular gusto, Haidt measures ten 'Great Ideas' against past/present research in psychology and science. "LJ" 's verdict: Dr. Phil et al. don't have diddly on the old-school sages. No man is an island, indeed, and no modern reader should be without this carefully considered demystification of life" Library Journal Best Books 2006

Most helpful customer reviews

268 of 272 people found the following review helpful.
An Enjoyable Read!
By Dan Wallace
I saw Chris Anderson (Wired Editor and TED co-founder) asked by Charlie Rose to name his favorite book of the last few years. "The Happiness Hypothesis" was the immediate response. Now this book is one of my favorites, too. The Happiness Hypothesis compares traditional philisohpical traditions with the lastest scientific discoveries, and the two ends meet well in the center. The author's own experiences provide narrative glue.

A major finding is that happiness is a set point for us, and that after good times and bad, we tend to return to our general level of happiness. At the same time, we can do things that help or hurt our happiness, and we can understand better how our minds and emotions work.

Factors that decrease happiness include persistent noise, lack of control, shame, dysfunctional relationships, and long commutes. Strong marriages, physical touch, meaningful relationships and religious affiliation tend to improve happiness. Activities with others enhance our happiness; status objects tend to separate us from others.

In terms of parenting, Haidt finds that secure children are well supported by parents who are nearby, providing safety and security. Avoidant children are neglected by their parents. And resistant children have parents who alternate between support and neglect. Haidt also shows how moral relativism is not good for children.

I was also fascinated by Haidt's observation that modernity and commercial culture slowly replaced the ideal of character with the idea personality, leading to a focus on individual preferences and personal fulfillment. This movement reached a height during the "values clarification" movement of the 1960s which taught no morality at all. The result of this is "anomie," a lost sense of self and right or wrong and feeling of being detached from other people and the world.

One of the most hopeful sections of the book talks about Martin Seligman's work on positive psychology, and the rediscovery of virtue. Seligman and Chris Peterson researched wisdom traditions and found that these six virtues are common across almost all cultures: (1) Wisdom; (2) Courage; (3) Humanity; (4) Justice; (5) Temperance; (6) Transcendence. These six categories serve to organize 24 character traits. (You can find the complete list on Wikipedia.) The conclusion is that you should work to cultivate your strengths, not your weaknesses. This area of study is a great breakthrough after 100 years of the psychological study of mental illness.

There were also many insightful nuggets I found in the excellent book, including:

- How oxytocin, cortisols and endorphins effect health and behavior.
- Haidt's belief that the chief causes of evil are moral idealism and high self-esteem.
- Letting off steam makes you angrier, not calmer.
- Wisdom is the ability to adapt, shape the environment, and know when to move to new environments.
- Pleasure comes more from making progress toward goals than from achieving them.
- Social constraints enhance happiness; total freedom decreases happiness (an insight seconded in "The Paradox of Choice").
- Trauma has benefits in that it shows how much adversity you can cope with. It also filters out false friends and changes priorities and philosophies toward the present.
- Passionate love cannot last; companionate love is what lasts.
- Haidt sees two types of diversity, demographic and moral.
- The three major dimensions of social relationships are liking, status and morality/ transcendence. Coherence across these spectrums leads to happiness.
- The six basic emotions that can be read on the face include joy, sadness, fear, anger, disgust and surprise.
- Happiness often results from the collective elevation in a church or political rally.
- The three levels of work are a job, a career and a calling. The more autonomy at work, the more happiness.
- Vital engagement in the world leads to love made visible, which is a sign of deep happiness.
- Work that does good for others and leads to income and recognition will enhance happiness.
- Apostates who try to leave a group and traitors who undermine a group are subject to atrocities.
- Group chanting can lead to mystical experiences, which provide a sense of spiritual connection that leads to happiness.
- Eastern views and conservative politics focus on the collective, while Western views and liberal politics tend to focus on the individual.
- Volunteerism increases happiness, and service learning in schools reduces dropout rates.

This is a brilliant and sweeping narrative, and well worth the read. The cross-disciplinary nature of this work reminds me of EO Wilson's seminal work, Consilience. And parts of this book remind me of one of my favorite books of contemporary philosophy: Status
Anxiety, by Alex de Bouten.

Status Anxiety
Consilience: The Unity of Knowledge

6 of 6 people found the following review helpful.
I truly loved the book.
By Brian Johnson
[[VIDEOID:9422f9c9cd9a77a3954a14d807c67011]] “Where does happiness come from? There are several different “happiness hypotheses.” One is that happiness comes from getting what you want, but we all know (and research confirms) that such happiness is short-lived. A more promising hypothesis is that happiness comes from within and cannot be obtained by making the world conform to your desires. This idea was widespread in the ancient world: Buddha in India and the Stoic philosophers in ancient Greece and Rome all counseled people to break their emotional attachments to people and events, which are always unpredictable and uncontrollable, and to cultivate instead an attitude of acceptance. This ancient idea deserves respect, and it is certainly true that changing your mind is usually a more effective response to frustration than is changing the world. However, I will present evidence that this second version of the happiness hypothesis is wrong. Recent research shows that there are some things worth striving for; there are some external conditions of life that can make you lastingly happier. One of these conditions is relatedness—the bonds we form, and need to form, with others. I’ll present research showing where love comes from, why passionate love always cools, and what kind of love is “true” love. I’ll suggest that the happiness hypothesis offered by Buddha and the Stoics should be amended: Happiness comes from within, and happiness comes from without. We need the guidance of both ancient wisdom and modern science to get the balance right.”

~ Jonathan Haidt from The Happiness Hypothesis

That’s officially the longest intro quote of any of the Notes I’ve created so far but OMG. Makes you wanna read the whole book, eh?! :)

Jonathan Haidt is a leading positive psychology researcher/professor at the University of Virginia and this book is an incredible look at ten “Great Ideas” from ancient wisdom that he brilliantly analyzes in the light of modern science while helping us apply the super practical stuff to our 21st century lives. It’s a great blend of intellectual rigor, philosophical wisdom and nuts and-bolts practicality that I highly recommend.

If this Note resonates with you, I *definitely* think you’ll love the book. I put it up there with Sonja Lyubomirsky’s How of Happiness and Tal Ben-Shahar’s Pursuit of Perfect and Happier as some must-read positive psychology goodness.

Here are some of the Big Ideas:

1. The Rider & The Elephant - Learn to ride your elephant!
2. Epiphanies - And lasting change.
3. Meditation - The magic pill.
4. Cognitive Therapy - It works.
5. Pulling the Splinter - The joy of taking responsibility.

Let’s get clear on our ultimate purpose and move toward it, lest we step in other people’s elephant poop, yo! :)

More goodness— including PhilosophersNotes on 300+ books in our ​*OPTIMIZE*​ membership program. Find out more at brianjohnson . me.

5 of 5 people found the following review helpful.
Psychological Tools that don't quite deliver Wisdom
By Rich
I really wanted to like this book more than I did. This book promises an exploration of ancient wisdom through psychology, but what it ultimately delivers is a discussion of various studies, many of which any reader who has taken Psych 101 will already be familiar with. I found the psychological discussion at times interesting and some of the principal concepts have significant potential--the divided self, the relation between reason and emotion, the tension between the vast ages of human evolution and the short termism of modern human life, but these themes are ultimately never fully developed. At other times the psychological discussion is quite tedious, with pages dedicated to summarizing psychological studies that could fit in a paragraph. Moreover, the "wisdom" was generally a summary of scientific research with some shallow nods to Buddhism. Consider this passage:

"Buddha got it exactly right: You need a method for taming the elephant [subconscious will], for changing your mind gradually. Meditation, cognitive therapy, and Prozac are three effective means of doing so."

Prozac? Really? This is not wisdom, this is psychology at its most superficial. (The author's reasoning for advocating Prozac is that studies suggest human beings are naturally subject to a spectrum of dispositions, some happy, some not. So a little chemical tweak may be what certain poor saps who have "lost" the "genetic lottery" might need to perk up. What the author fails to explain, however, is why it is necessary to take a naturally occurring spectrum of happy and unhappy people and feed pills to some of those people in order to make them conform to a desired level of happiness. And THAT, is where the wisdom part should come in, but it never does.) No wonder, the book's discussion is entirely based on the cold calculated studies of cognitive science. If you want wisdom, I'd suggest you drift to the psychoanalytic wing of the profession or just go straight to the Bhagavad Gita. One thing is certain: Buddha won't tell you to eat Prozac.

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dinsdag 16 augustus 2011

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THE MEANING OF FLOWERS, by Claire Powell

Book of poems

  • Sales Rank: #2838854 in Books
  • Published on: 1979-09-12
  • Released on: 1979-09-12
  • Original language: English
  • Number of items: 1
  • Binding: Paperback
  • 181 pages

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zondag 14 augustus 2011

[M756.Ebook] Free PDF Renunciation and Power: The Quest for Sainthood in Contemporary Burma (Yale Southeast Asia Studies Monographs), by Guillaume Rozenberg

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Renunciation and Power: The Quest for Sainthood in Contemporary Burma (Yale Southeast Asia Studies Monographs), by Guillaume Rozenberg

This monograph explores the identity of a seemingly paradoxical figure: the Burmese Buddhist saint, who departs for the forest to combine harsh asceticism with radical world renunciation, yet also seeks active involvement in the affairs of society. Examining the trajectory and work of eight living monks committed to the quest for salvation, Rozenberg contradicts representations of Theravada Buddhist saints as single-minded pursuers of nirvana. On the contrary, he shows how work for the temporal welfare and spiritual advancement of all is integral to a Burmese saint's identity. The saint predicts winning lottery numbers, redistributes goods donated to him, and develops building complexes essential to the spread of Buddhism. Throughout the book, otherwise obscure notions of spiritual power are reconsidered and explicated in a Burmese context.

  • Sales Rank: #6381574 in Books
  • Published on: 2010-08-31
  • Original language: English
  • Number of items: 1
  • Dimensions: 9.25" h x 6.25" w x .75" l, .95 pounds
  • Binding: Hardcover
  • 180 pages

About the Author
Guillaume Rozenberg has been a researcher with the French National Center of Scientific Research since 2004, and is a member of the Center of Social Anthropology (LISST) in Toulouse, France. His research focuses on figures of Buddhist sainthood and related cults in contemporary Burma.

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0 of 0 people found the following review helpful.
Full of interesting information you won't find elsewhere
By Barbara
This is NOT « a day in the life of a monk in Burma » it is written by an ethnologist about monks and their place in Burmese culture and the interdependence between monks and laymen which is at the heart of Burmese society. The book is at times academic, a bit complicated, repetitive, but full of rich information that I got nowhere else. For example, the three areas where there is a strong interdependence: prediction, redistribution of wealth, and building religious structures. I learned about the weikzas, with their supernatural powers that are just as intriguing as the nats. There is a good chapter on the relationship between the government and powers that be and the monastic community, from the time of Bagan to the present day.
The book is illustrated with the stories and examples of eight of the most revered monks in Burma, one of which, Thamanya Hsayadaw, is the spiritual counselor for Aung San Suu Kyi, and his city of 15,000 was put forward by her as the Ideal City.

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dinsdag 9 augustus 2011

[K424.Ebook] Ebook Download The God Who Failed: An Assessment of Jawaharlal Nehru's Leadership, by Madhav Godbole

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The God Who Failed: An Assessment of Jawaharlal Nehru's Leadership, by Madhav Godbole

No leader of independent India has towered as high over Indian politics as Jawaharlal Nehru. Highly educated and articulate, he had a deep understanding of the history and culture of India and was responsible for laying much of the foundations on which today s India is built an enlightened Constitution, parliamentary democracy with adult suffrage, and secularism.

However, of equal significance are Nehru s failures, for which he and his admirers have been increasingly criticized since the turn of the century. These include the imbroglio that took place when Kashmir became a part of India; the Indo-China border dispute of 1962; his overlooking the growing menace of corruption on his watch; and Nehru s futile pursuit of his own brand of dubious socialism.

The God Who Failed: An Assessment of Jawaharlal Nehru s Leadership provides an objective and unbiased look into Nehru s legacy his triumphs, his failures, and his unfulfilled vision for India. Written by the veteran administrator and author Madhav Godbole, this book is a powerful account of the leader who shaped modern India as we know it.

  • Sales Rank: #3966530 in Books
  • Published on: 2014-11-01
  • Released on: 2014-12-11
  • Original language: English
  • Dimensions: 9.00" h x .94" w x 6.00" l, 1.36 pounds
  • Binding: Hardcover
  • 374 pages

About the Author
Madhav Godbole holds an MA and PhD in Economics from Bombay University and an MA in Development Economics from Williams College, USA. His distinguished career has included assignments such as Secretary, Petroleum and Natural Gas; Secretary, Urban Development, Government of India; Principal Finance Secretary, Government of Maharashtra; and Chairman, Maharashtra State Electricity Board. He is the author of sixteen books in English and Marathi including Good Governance: Never on India s Radar (2014).

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1 of 1 people found the following review helpful.
A refreshing look at Nehru
By Milind Sathye
Godbole's book is refreshing...It is hard to find unbiased journalism in India.. It is important that deification of any one howsoever tall the leader may be doesn't take place. Unless a person's life is viewed from a different lenses, it would be hard to know the truth. The books so far on Nehru are just one-sided account of his greatness and compete with each other in eulogizing him. It is understandable from mercenary authors, given that Nerhu's future generations occupy the throne directly or indirectly. Godbole however provides a 360 degree view of Nehru. It is quite common in western countries to provide such an account of their leaders howsoever tall they may have been. It never happened in India earlier. One may or may not agree with Godbole, neither his views would diminish the stature of Nehru but the book does provide a refreshing reading experience when compared with those written by sycophants of the Family. A must read for any one who is tired of reading sycophantic accounts of Nehru.

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zaterdag 6 augustus 2011

[K726.Ebook] Ebook Free Classic Teddy Bear Designs-Heirlooms to Make & Dress, by Estelle Ansley Worrell

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Classic Teddy Bear Designs-Heirlooms to Make & Dress, by Estelle Ansley Worrell

Projects for the beginner to the advanced bear making aficionado. Includes full-size project patterns for 24 bears (both jointed and non-jointed) ranging from 3-1/4-18" as well as complete wardrobes for each. Gives a concise history of teddy bears and their clothes. 22 color and 101 b/w photos. 150 pages.

  • Sales Rank: #1551382 in Books
  • Published on: 1986-07-01
  • Original language: English
  • Number of items: 1
  • Dimensions: .62" h x 8.25" w x 10.84" l,
  • Binding: Paperback
  • 150 pages

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19 of 19 people found the following review helpful.
VALUE FOR MONEY, BEGINNERS BOOK ON BEAR MAKING
By A Customer
This would have to be the best value for money, beginners book on bear making that has been published in the last 10 or more years. The author has written this for the home sewer and doesn't assume that there is a teddy bear supplies shop just up the road where you can buy those expensive specialty items like joint sets, mohair fur, etc. Everything you need can be found at home in the sewing cupboard, at the local sewing shop or general store; eg: like buttons for joints, teddy jumpers/sweaters out of socks.
There are numerous bear patterns of various sizes; eg: dad, mum & baby; both jointed and unjointed, along with clothes patterns for just about all of them! Estelle also explains how to customise the clothes patterns for different bears and garments; eg making a shirt into a coat. I still use this book if I want to dress bears from other patterns. For example I compare the bear that I'm making with Estelles bear pattern pieces; ie leg to leg for trousers, body to body for dresses or jump suits, etc; and when I find one that is similar I use the clothes pattern that fits Estelle's bear as a base clothes pattern for the bear I am making.
The bear patterns themselves are excellent for beginners as all the bears a quite chubby (makes for great cuddling!), so are easier to sew, to turn inside out and to stuff - no narrow nooks and crannies to make for difficult stuffing. Some of the head patterns don't have a full head insert ie down to the nose, again making for easy sewing and more chance of a "nice muzzle/nose" for a beginner.
Virtually all the bears in the book are made from something other than mohair, either synthetic fur, felt, coat fabric, etc, so you get a pretty good idea of what your bear will ACTUALLY look like. Mohair is gorgeous, but is often deceptive as it is usually a woven fabric, which doesn't stretch, so if you use synthetic fur, felt or coat fabric, for example, you end up with a very different bear to the mohair one you are hoping to reproduce.
(I have a 1980ish edition of this book around which this review is written. PLEASE NOTE: there may be changes to the later edition SO the comments in the following paragraph may not be correct for this more recent edition.) Full colour books are the norm these days, so it is disappointing there aren't MORE of the gorgeous colour photos - although there are still plenty of black and white ones. There is quite alot of text, (including the usual "teddy bear" history), which comes under logical headings so it is generally easy to find info on subject. All the patterns are on pages of the book - great - no misplaced pattern inserts.
This is a value for money book - lots of bear patterns with clothes patterns and how to do's. You won't make a Stieff reproduction, but you will get lots of practise with the numerous options this book offers.

1 of 1 people found the following review helpful.
Making Teddy Bears and clothes
By L. M.
The things I liked about this book is it goes into history of Teddy Bears.
Seems to have good instructions on contructing your bear and the clothes.
It has a lot of cute clothing patterns including sweaters for your bear and how to make them from your old sweaters.

My only con and it's really not a big deal, is that as it's an older book it doesn't have as many step by step photos as the newer books seem to have. It does just not as many. And much of it is in black and white. Still, it seems to have a lot of useful information.

I am very new (extremely) to bear making and am not an experienced sewer. But I love the bears!

1 of 1 people found the following review helpful.
This is a fantastic book for people learning to make bears
By Heather Hilburn
This is a fantastic book for people learning to make bears. I really love the miniature bear patterns, the jointed bear with the hidden buttons, as well as the realistic bear. There are good instructions for making bear clothes from human clothes, even thought I never cared much for dressed teddies. Mine are little nudists, but some of the clothes are highly tempting!

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donderdag 4 augustus 2011

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Zwetschgendatschikomplott (Franz Eberhofer 6), by Rita Falk

Zwetschgendatschikomplott (Franz Eberhofer 6), by Rita Falk



Zwetschgendatschikomplott (Franz Eberhofer 6), by Rita Falk

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Zwetschgendatschikomplott (Franz Eberhofer 6), by Rita Falk

Der Rudi zieht um - und zwar ins Münchner Schlachthofviertel. Vom Balkon aus beobachtet er die Krähen, die über den Fabrikdächern kreisen. Dahinter schönstes Alpenpanorama. Doch mit der Ruhe ist's schon wieder vorbei, als ihm eine der Krähen einen abgetrennten Frauenfinger zu Füßen legt. Wie sich herausstellt, gehörte der Finger einer Prostituierten, die mit einer mysteriösen Waffe erstochen wurde. Und so ermitteln Rudi und Franz im Münchner Rotlichtviertel - aber erst Franzls Liebschaft mit einer Ex-Prostituierten bringt sie auf die richtige Spur. Und die führt direkt auf die Wiesn.

Der sechste Fall für Franz Eberhofer: wie immer a Mordsgaudi!

  • Sales Rank: #105330 in Audible
  • Published on: 2015-03-06
  • Released on: 2015-03-05
  • Format: Unabridged
  • Original language: German
  • Running time: 464 minutes

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Five Stars
By Elke75
Super, wie immer! Kann es nicht erwarten bis das nächste Buch veröffentlicht wird.

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Five Stars
By Maria Georgi
amazing book!

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